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If you are over sixty, you probably don’t like to have your picture taken. Older faces are prime victims to harsh lighting, deep shadows, sharp lenses and unforgiving close ups. You probably look fine at night with candle light on your face but once your grand daughter shows up with her digital camera, your pleasant image is history. Arcsoft, Adobe and Corel all sell image editors with the necessary tools.
There are a few measures you can take to alleviate the situation. One is to insist on a full length shot far enough away to produce a small and indistinct face. Another is to slather on the make up and hope for the best. Finally, you can beg to be out of the picture. This last punishes you as well as your loved ones and makes one look vain.
A favorite picture of you that everyone likes can be improved digitally quite easily. It just requires a little effort on the photographer’s part to familiarize yourself with the necessary tools and methods.
Starting at the top, there are stray hairs and dark roots ruining the hair dew. Stray hair is easily cloned out of existence by copying the adjacent area with a feathered clone stamp set at fifty per cent transparency. Dark roots require cloning an area of the hair of the proper color and running in the same direction if straight. I recommend a thirty per cent transparency using several passes for a realistic effect. Work at the highest enlargement of the working area that fits on your screen.
Shiny foreheads are tricky, but can often be improved with a touch of the disturb brush. Set the brush at medium strength and at fifty per cent transparency. Place the size at twice the area of the highlight and feather at 100%. Don’t try to darken the area but a slight fill with the air brush will do wonders. Use the eye dropper to choose an adjacent skin color and fill in the highlight at three per cent transparency.
Blemishes will disappear using the clone at seventy per cent transparency, copying from a near by unblemished area of skin. At eighty five per cent transparency, drag the clone over the bags under the eyes for a younger look. Don’t over do this effect.
The whites of the eyes can be lightened if done carefully. Outline the whites of the eyes with the dotted line mask and make an object of the masked areas. In the brightness/contrast box click on the brightness once at three per cent. Don’t try to make any other adjustments to this area of the eyes. It is possible to open the eyes somewhat but the method is quite advanced. If there is no highlight in the eye, you can place one with a two or three pixel brush using a light warm gray color. A round 100% feathered shape is normal or a crescent shape for an out of doors picture. If the highlight looks too prominent you can use the softener brush to dull it down without removing it.
Teeth often come out dark and yellowish in digital photographs. Draw a dotted circle around the teeth and using the brightness/contrast box, lighten the teeth at five per cent strength and change the color balance with a three per cent magenta adjustment. Crooked teeth can be fixed by reverse cloning a good tooth from the other side of the mouth. However, this method requires a little practice and advanced training to be successful.
Too pale skin can be corrected by using the histogram center arrow. Slide this arrow slightly to the right for darker skin. Conversely, sliding it to the left will darken the middle tones for a simulated sun tan. The ends of the histogram representing the whites (right side) and blacks (left side) remain attached to the extreme ends.
There are other effects that will improve the face. The softening brush used judiciously will smooth the skin, the soft focus filter has the same effect but might be too strong a result. The color balance can be used to warm up the face by masking the face and head and adjusting the color balance two per cent yellow and two per cent red. If the effect is too noticeable, try one per cent. Remember blemishes, windy conditions and dark shadows are temporary conditions. A photograph is forever.
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Only you are able to decide which path is best for your needs, but do keep in mind that the herbal approach is safe to undertake and has many benefits. What are some of these benefits? The herbal approach uses the endocrine system of your own body to increase your breast size naturally and safely, adding size, firmness and fullness. It is your own tissue growth. Your body does it by itself. The results are long lasting and you have your own naturally larger breasts.
The most dramatic and unique effect of the herbal approach comes during the early stages while your body is changing. As you begin to see and feel your body shape changing, a new and wonderful relationship with your body takes place. Your body is like a new friend, bringing you new levels of happiness every day while providing delight in the gradual changes taking place. It is a journey of body re-discovery, as what has often been merely a dream now becomes a reality. Even more than the tangible physical changes that take place to your appearance, you begin to realize a daily increased feeling of self worth. Other important benefits include the safety of using all natural ingredients, comparative cost effectiveness, and heightened feminine physical sensations in the breast area and throughout the body.
Why Choose Herbal?
When beginning your journey of transition, you are offered a barrage of options to consider. Though temporary, the choice of breast forms is the most easily accessible. Hormone therapy is another choice available to you, characterized by high cost and a level of physical risk. The more drastic alternative of breast implants comes with a high level of complications and risk over a lifetime. Breast implants can be cost-prohibitive and need further surgical intervention often in 3 to 5 years and in at least 8 to10 years. And then there’s the herbal approach, which can result in substantial and impressive results with significantly lower risk, minimal cost and virtually no adverse side effects.
Using all-natural herbs, significant long lasting results of up to two or more cup sizes are being routinely reported. The percentage of people who are getting good or excellent results approaches close to 100% satisfaction for herbal breast enhancement programs that are individually monitored and adjusted. The most successful programs use ingredients based on concentrated herbal extracts that are 10 times the strength of standard herbs.
A personalized herbal program is about a tenth of the cost of breast implants. The safe, non-invasive and low cost herbal approach has many advantages not found in any other method. The herbal approach is the only one that heightens breast sensation so that you feel the same sensual and sensory effects in the breast area that are normally experienced only by women. Surgical implants will reduce sensation to the breast area and almost always result in a partial or complete loss of sensitivity. By way of comparison, herbal breast enhancement has few if any side effects. Other than some temporary tingling, itching, or even soreness felt in the breast area, a normal occurrence while your breast size is increasing, you will notice softening of the skin and hair, rounding of the hips and a noticeable increase in sexual libido.
So you’re thinking, “Sounds great, but how does it work?”
How Does It Work?
Estrogen, often thought of as the “female” hormone, but also present in males, is critical for sexual functioning, boosts the immune system and supports bone growth. Estradiol is one of sixteen different types of human estrogen. It is the estrogen responsible for a long lasting size increase in the breast area.
The key to a natural and long-lasting breast size increase is stimulating the body to produce a large quantity of its own human estradiol. When human estradiol production increases beyond the necessary threshold level, it will go to the breast tissue where it binds to the estrogen receptor sites. Every person, regardless of sexual orientation, has literally millions of unused estrogen receptor sites in the breast area that can be used for size increase.
Most herbal products found in today’s market do not contain the necessary component that stimulates the endocrine system to produce its own human estradiol, but rather offer only phytoestrogen, or plant estrogen. Human estrogen is from 200 to 1000 times more potent than phytoestrogen and bonds strongly to the estrogen receptor sites in the breast tissue. The drawback to just using phytoestrogen-based herbals for breast enhancement is their inherent inability to bond strongly to the human receptor sites for any length of time. Although these plant estrogens will go to the breast tissue and provide temporary results, you will have to constantly use these products to maintain any size increase.
So how do we get long lasting results?
We tap into the power of your human body as an efficient biological factory. With our personalized program we introduce a separate set of herbs that are adjusted for each person’s body to stimulate the body’s endocrine system to produce its own human estradiol. Now, when your body finds the plant estrogen we bring into your program it will use it as the ideal building blocks for creating your own human estradiol. When your body produces its own human estradiol you achieve long lasting results.
When the correct amount of concentrated phytoestrogen is readily available in the body, the body uses very little energy to produce a large quantity of human estradiol. The results are your own naturally larger breasts, made from your own breast tissue. It is real, it is natural, you did it yourself, it is long lasting and it is authentically you.
What to look for in an effective herbal breast enhancement product:
Dosage: The best products for TG use are based on herbal ingredients that are highly concentrated extracts. Herbal breast enlargement products not based on extracts are usually too weak to give significant results for TG. A typical women’s formula will deliver less than 200mg a day of the needed ingredients, while an effective TG program will provide ingredient dosages in the range of 15,000mg to 20,000mg a day. Without using concentrated extracts, the conventional capsule requirement could be an impractical quantity of 100 or more capsules a day.
Ingredients: You will find Saw Palmetto in almost all of the herbal formulas available in the market. It is one of the richest sources of plant estrogen. Other significant and common working ingredients are Wild Mexican Yam, Fenugreek Seed, Fennel Seed, Pueraria, Red Clover and Avena Sativa. However, to get a long lasting result, the single most important herbal ingredient is Lepidium Meyenii, commonly known as Maca. Be sure your breast enhancement program includes Maca in an extract 10:1 concentrate. This is the most important ingredient for attaining results that will last for years. With Maca present and adjusted to the proper personalized dosage, you will not have to continue on any herbal regimen once you have achieved the size you want.
Starting Evaluation: A successful program should include a personal evaluation. Because each of us is unique, it is important for you to choose an herbal program that will factor such details as your age, weight, height, metabolism and level of physical activity, as well as your breast size objectives and goals. Other factors affecting personalization are caffeine and nicotine use as well as digestion and any other issue that might adversely affect an individual’s personal progress.
Follow Up: Follow-ups are a crucial part of any successful breast enlargement program. Each individual’s program should be reviewed in 30-day intervals for analysis of individual progress and to assist in what can be done to help the client get the best results possible. Your customer service representative should be knowledgeable. You should have personalized treatment. Be sure the sales staff members are not merely “order takers” but consultants that care about your progress and success. Toll free access to your personal consultant is an equally important factor in choosing your program.
Results: Are the results long lasting? A properly formulated and administered program should take about 180 days to get the long lasting results you want. The most effective breast enlargement programs will strongly stimulate the body to produce its own human estrogen. This in turn will convert any phytoestrogen that is provided by the breast enhancement program into human estradiol, which gives you long lasting results. You only have to take those products until you get the size you want and then you can stop taking the product while keeping the size you achieve. Effective programs have achieved results that are very near the 100% success rate.
Product Comparison: Do your research. There are significant differences between breast enhancement products. Look carefully at the ads & call the companies that advertise with us to compare. Remember to look for the information you have just read and then make your choice with wisdom and care.
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Chapter Seven
Lilli Ann [Work and Play and Colleen]
Many things were starting to happen after the tournament was over. It seemed my life had stopped for a moment in time. I had been working five to six days a week, mostly five. Met a guy, my age called Dan, at the karate studio one evening, he was just watching, and we got talking, and I helped him get a job at Lilli Ann. He was assigned to Mr. Green and would eventually be reassigned down stairs in the packing department. I was assigned in another department, which was one floor lower than his. He started falling in love with a Spanish gal, and wanted me to help him out by asking her why she was so down right rude to him. And so I did, it must have worked because they started dating, thereafter.
Well Dan’s brother came into town, he was eighteen-years old, and again Dan and I were both twenty-one. The landlord would not allow two people in their apartment so I talked to my landlady and they ended up renting out the big room. I liked them both, but Dan was a little more level headed. His brother smoked pot night and day, Dan occasionally.
About this time my mother said she was coming down to visit me after Christmas, which was not too far off. And so many things were happening. And as the weeks passed by I would often go downtown San Francisco after work and go to the double feature movies, they were older ones but very cheep, .75 cents during the day, before 6:00 PM, and afterwards walk around. I can remember a few times walking down a side street by a little café and Hell’s Angels were hanging out there. One time one of the Hell’s Angels, gave me a strange look but paid me little heed, and went back playing some kind of game. I had to walk around all the motorcycles for they hand them parked in the street, on the sidewalk, and every which way… and them seeing me trying to dodge the bikes to get around them, probably gave them a little groan, one that might have meant, ‘…don’t tip them over sunny.’ And I didn’t bump any.
At work a few of the Spanish gals up in Mr. Green’s area were eyeballing me up, but I found out they were married and so I paid little attention to them afterwards. And a few Japanese girls, older women talked to me often, but I never got to dating any of them. Then one evening, after work, Colleen with her sparkling white Catholic seen me waiting for a ride by a street car stand, and asked where I was going, I said down by mission street, and offered to give me a ride. She was around thirty-three years old, whit a healthy looking body, and was hunting I presume—that is, looking for something.
Colleen
As she drove down Mission Street, she knew exactly where Lilli Ann was, I guess many people did, it was very famous for women’s exclusive clothing, they had dresses in Harpers Bazaar, some famous magazine, and advertised in London, Paris, New York, and here in San Francisco. I closed the window a bit in the car, the air was cool this morning, I told her, but I shouldn’t complain, it was nothing like Minnesota; for weather in December at 57 degrees is like heaven sent; I had heard them say on the radio, that it was going to get to 66 degrees before the end of the day. Not bad, in Minnesota we’d have about forty inches of snow by now, and most likely it would be about three to five below zero. January was the coldest month, in Minnesota usually, reaching many times ten degrees below zero or lower, and February had all the snow it seemed, sometimes twenty inches in one month; sometimes sixteen inches in one day. Some years we had ninety inches of snow.
I was inclined to ask her for a date, even though she looked much older than I, but she said first, as I opened the door to get out,
“Do you drink wine?”
“Occasionally,” I said, for I used to drink some back home, but it was that cheep Ripple crap or Thunderbird, rotten gut stuff. But I didn’t want to tell her that.
“The dry wine is even better than the sweet if you have the right bottle, and it’s aged some…” she added as I stood up next to the car, “I’ll pick you up after work, say 4:30 PM, does that sound good?” What could I say, the Cadillac girl was leading, and I had nothing better to do. I hadn’t gone to karate practice going on three weeks now. I think Yamaguchi was a little disappointed in me, surely not his black belt bunch though.
“Ok,” I said as I started to turn around and walk inside of the three story building. Things were always happening so fast these days I hardly ever questioned anything. Dan had me meet a friend a week ago, some guy who was selling dope, pot or whatever, we talked and he offered me a job at twice the amount I was making, but I turned him down, I didn’t want to be his or any bodies body guard, end up dead with some heroin stuck in my ass, or down my throat. This was safer, work here at $.1.75 per hour, and just enjoy life; live longer.
It was funny, when I stopped to talk to a young man, my age who wanted a quarter, and back in those far off days, they were all over San Francisco, --at any rate, I told him to go get a job, and he asked how much I made in a week, I said $70-dollars, and he laughed, saying: “I make more than that in a day, $75.” Oh well, I guess I still have values. I just couldn’t sit down on the street corner and beg; it wasn’t even a thought. Or should I say, it never occurred to me.
٭
The day went fast, Dan was flirting with his new Spanish girlfriend, who worked in the office at Lilli Ann; I think she was happy I set them up, but I was a little jealous now, I guess I would have like to date her, but I was always drinking, going to movies, and before karate, running around town. No real time I suppose. I think she was wondering why I didn’t smile as much as I did before when I met her halfway going up and down the stairs a few times a day. But I tried. My mother wrote and said he’d be in town now in January. Not too far off.
It was 4:35 PM, I just slammed the heavy door behind me to Lilli Ann, and there on the street was that white Catholic, and Dan was not too far behind me, he’s seeing me go to the car, I told myself, not looking in back of me, I’ll hear about it tomorrow.
“See yaw later Chick,” Dan said, I think it was to get Colleen’s attention; I turned around and smiled a bit and shook my head.
“I did show up, didn’t I, I bet you thought I wouldn’t?” Said Colleen.
“Not sure what I thought,” I admitted, and I seem to put on a dumb look.
“I always like wine in the fall, --woops, soon to be winter in a week or two.”
“Always --” I said-, opening up her car door, and getting in.
“Always my new friend, now let’s go to the Bay and look at the Golden Gate.” I nodded my head yes, for I even liked walking along the bank and dock area, by the railroad tracks also.
As we got to a certain spot, evening was starting to set in, the once white clouds were turning light-gray, and I opened up the window a little. I loved to grab the moment, absorb what was happening. San Francisco was so very much different than my conservative St. Paul, and it seemed like I was starting to own it a little. There in front of me was the beautiful Golden Gate Bridge, I would never forget it. I had walked across it, seen it a dozen times, and I just never got tired of it; but one thing, I only walked across it once, it is far…longer than one imagines. It was a settling evening. The cars with their horns, the people at work, I was starting to calm down. The night was creeping in. On one hand I was hoping it would never end, and on the other hand, it was a fast pace city for me, it could slow down a bit.
“Are you thirsty Chick,” said Colleen.
“Oh yes, very much…” I took the bottle from her and drank right out of the top. She pulled out two glasses, then hesitated, and put them back in her back seat saying, “We really don’t need them I see.” I guess I might have seemed a little uncouth, but it was me.
For awhile we talked about the earth quake everyone was talking about; how the evangelist’s were saying San Francisco was going to be sunk to the bottom of the ocean. Many people were taking long vacations to get out of town. It was supposed to be on a certain week end coming up (or within the month of January). They talked about it at the bar, at Lilli Ann, every where.
She smile, said,
“Of course,” as she took a drink. I think she was thinking about her youth; --for whom at twenty-one runs around looking for a glass when you got a bottle. We sat just drinking, and looking at the Bay and the bridge, silent for awhile, some people don’t like too long of a period of silence, but it can be golden, --she lit a cigarette, and so did I, and we took turns drinking. She told a few dirty jokes, and I pretended to think they were funny, and when she laughed I laughed, not because they were funny, but because she was.
She commented, “You’ll have to let me know when they have the fabric sales down at Lilli Ann, I want to buy as much as I can.” I didn’t quite understand what she was talking about then, but I did find out later on that they had sales about every four months, and employees could buy fabrics not usable. I would however purchase some for her, during our short time romance.
“Let’s go eat,” she commented.
“Where…” I said.
“I’ll pick up something at a store or restaurant.”
“That’s perfect,” I replied, as I put the cork back into the bottle, there was not much left to the wine.
Colleen stopped in front of a fancy restaurant, --went inside and ordered some burgers made up for us.
“Dolores Street right,” she asked, and I gave her the address, “They’ll taste better relaxing at your apartment.” She said. I explained she was welcome but I only had a small room, and my friend, whom was Dan, she remembered the person who had said, “By Chick”, lived in the other room next to me, --I explained we shared bathrooms.
“So she rents out rooms,” she commented.
“Yaw, why, you need one?”
“Not quite yet, but could be soon, or in a month or so,” she ended her replied with.
As she stopped in front of the mansion I lived in, my hunger had changed from food to lust, or so it seemed, the burgers did not seem at all appealing; none the less, we went directly to my room.
As we entered the room she looked about, “Quite cute, and yes, you were not kidding, it is small, but cozy, enough for a single man. I had a little dresser by the side of the bed where I kept an ashtray, and a light, along with a little radio. A closet in along side of the bed, a little to the right of the doorway you might say, a window behind me overlooking my bed, and the door to the bathroom on the right also, of the bed; --if I was laying on my back I’d be looking at the doorway in front of me
She put the burgers on the small table, took a last drink of the wine, gave it to me, there was one swallow left, I drank it, as she undressed, then she jumped under the covers. She had big breasts and a semi tight body for her age. She was not thin, nor fat, quite healthy looking. I got a hard-on immediately, and like a dog in heat, we pulled our lust together and she grabbed my item and directed it to her warmth.
We made love for about 45-minutes, and I fell to my side a bit, rested, and pulled her over to me again, and stuck my penis back into her private area. She was very warm inside, and my body shook as I climaxed.
“We should get some sleep Chick,” she said with a chuckle. It seemed she found what she wanted, but I felt a little out classed for some reason. She had a degree I had found out while sitting by the Bay over looking the Golden Gate and she worked as a legal assistant. I couldn’t sleep, so I looked at some of the roof tops of the houses out my window; San Francisco was very complicated for me, all its old and new mixed into a whole, and Colleen laying next to me. But I told myself to go to sleep, tomorrow was another day. As I rolled my body back under the covers, I could not hear anymore car horns, the radio was quiet, Dan and his brother must have fallen asleep, and his girlfriend gone home. The wind was making a bit of noise on the window sill, but that was tranquilizing, if anything.
Chapter Eight
The Christmas Party
Well, Dan was dating the Spanish lady, and Colleen was coming over picking me up on regular bases now. She even got to know the Colonel a little, and Dan and his brother Jack. I think she was eyeing up the little bedroom by Dan’s big room. In-between our dating that is.
During this period in San Francisco I was working, and I wasn’t seeing Goesi much, going to the movies as I usually did, and we had a Christmas party coming up in a few days. Mom had written and I expected her to be flying into San Francisco, in two weeks. From here she’d stay a week then fly down to see my brother in Montclair, Southern California.
The weather got a little colder also, but why argue it was still in the 50’s during the day, and low 40’s at night. Some rain but not much. I now was running the dogs for the Colonel; I had a hell of a time taking the “Beast,” out. I called him that because he was up to my waste when on all fours, and had teeth almost like a saber tiger; he looked more like a wolf than a dog. He ran like a horse, and I had a choke chain on him; --thank god I could run with him, I think he liked that. And people jumped every which way when they seen us coming: --and a few times he got away from me whereas the panicked started all around me, people jumping far away from the on coming beast, I didn’t blame them.
The Confrontation
I knew when I left San Francisco, I’d miss the dogs. Matter-of-fact, one night a neighbor came over and was hollering at the Colonel, and threatened her about the dogs, I was in the hallway upstairs listening, had a few beers in me, I came down slowly, and she told the guy to go because I was the one running the dogs, which the guy noticed, and that with my karate, and temper it might not work out too good if he sticks around;” adding, she said,
“I think he heard you hollering at me.”
“So what, let him come…” and then out of the blue I was five feet from him on the outside stairway, he was two steps down, and the Colonel was against the beam of the door way.
“You better take care of them dogs and shut them up before…”
“Before I kick you ass, that that…” I leaped toward the man with my hands in the air as to block the man if he thrust the knife at me, and landed on the second to last step, about two feet in front of him, and in a circular motion, threw several blocks to off set his focus, he jumped back, pulled out a two inch knife, he was terrified.
“You better not come closer,” he said. I started laughing.
“And you mister, better shut your mouth, go home and never, I mean never come around here again, and if I find out you’ve cause any trouble for my landlady, I’ll find you and stick that knife up your ass…….get out of her NOW!!” He moved as fast as he could. Yes, I had my wild moments, as most people have.
Said the Colonel, “I hope he doesn’t cause trouble for me, but I sure liked the way you handled him,” and she had a smile half a mile wide.
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Medical hair restoration in the literal sense includes the hair loss treatment which depends upon the use of medicines.
Unusual hair loss both in men and women is caused by the alterations in the androgen metabolism. Androgen is a male hormone which has a major role to play in regulation of hair growth or hair loss. The dermal papilla is the most important structure in a hair follicle which is responsible for hair-growth. It is the dermal papilla, the cell of which divides and differentiates to give rise to a new hair follicle. The dermal papilla is in direct contact with blood capillaries in the skin to derive the nutrients for the growing hair follicle. Research has shown that dermal papilla got many receptors for androgens and there are studies which have confirmed that males have more androgenic receptors in dermal papilla of their follicles as compared to females.
The metabolism of androgen involves an enzyme called 5 alpha reductase which combines with the hormone androgen(testosterone) to form the DHT (Dihydro-testosterone). DHT is a natural metabolite of our body which is the root cause of hair loss.
Proper nutrition is critical for the maintenance of the hair. When DHT gets into the hair follicles and roots (dermal papilla), it prevents necessary proteins, vitamins and minerals from providing nourishment needed to sustain life in the hairs of those follicles. Consequently, hair follicles are reproduced at a much slower rate. This shortens their growing stage (anagen phase) and or lengthens their resting stage (telogen phase) of the follicle. DHT also causes hair follicle to shrink and get progressively smaller and finer. This process is known as miniaturization and causes the hair to ultimately fall. DHT is responsible for 95% of hair loss. Some individuals both men and women are genetically pre-disposed to produce more DHT than the normal individuals. DHT also creates a wax-like substance around the hair roots. It is this accumulation of DHT inside the hair follicles and roots which is one of the primary causes of male and female pattern hair loss.
Blocking the synthesis of DHT at molecular level forms the basis for the treatment of MPHL ( male pattern hair loss) and FPHL female pattern hair loss). There are many natural DHT blockers and a number of drugs which are used for medical hair restoration.
Let us see the main drugs which are available for medical hair restoration in men and women.
Minoxidil
Minoxidil has the distinction of the first drug being used for promoting the hair restoration. This medical hair restoration treatment drug was used earlier as an oral antihypertensive drug, but after its hypertrichosis (excessive body hair) effects were noticed, a topical solution of the drug was tested for its hair growing potential. Minoxidil was then approved as medical hair restoration treatment drug for men by the US Food and Drug Administration (FDA) in 1988 as a 2% solution, followed by 5% solution in 1997. For women, the 2% solution was approved in 1991. Though 5% solution is not approved for women, it is used as a medical hair restoration treatment by many dermatologists worldwide. Both solutions are available without a prescription in the US.
Mechanism of action
Minoxidil is thought to have a direct mitogenic effect on epidermal cells, as has been observed both in vitro in vivo. Though the mechanism of its action for causing cell proliferation is not very clear, minoxidil is thought to prevent intracellular calcium entry. Calcium normally enhances epidermal growth factors to inhibit hair growth, and Minoxidil by getting converted to minoxidil sulfate acts as a potassium channel agonist and enhances potassium ion permeability to prevent calcium ions from entering into cells.
Thought the exact action of minoxidil preventing the formation of DHT has not been shown but the drug has been shown to have a stabilizing effect on the hair loss. The result of the drug takes about few months time to be evident since it is the time which is necessary for restoring the normal growth cycle of hair fibers.
Use of Minoxidil has approved by FDA for men (Norwood II-V) and women (Ludwig I-II ) older than 18 years. It is used as a medical hair restoration treatment either for frontal or vertex scalp thinning. It brings about an increase in density which is mostly caused by conversion of miniaturized hairs into terminal hairs rather than a stimulated de novo re-growth. The hair loss becomes stabilized after continued use of drug, which takes about a year’s time for the medical hair restoration treatment to show its complete results.
Hair loss restoration treatment with 0.05% betamethasone dipropionate and 5% topical minoxidil are found to be superior to minoxidil alone. Topical minoxidil is very well tolerated and adverse effects are mainly dermatologic. The most frequent adverse effect is an irritant contact dermatitis.
Though minnoxidil does not have any effect on blood pressure, it should be used with caution in patient with cardiovascular diseases. It is also contraindicated in pregnant and nursing mothers.
Finasteride
The drug finasteride was earlier used as treatment for prostate enlargement, under the medical name Proscar. But in 1998, it was approved by FDA for the Medical hair loss restoration in MPHL.
Mechanism of Action
Medical hair restoration treatments with Finasteride depends upon its specific action as an inhibitor of type II 5α-reductase, the intracellular enzyme that converts male hormone androgen into DHT (Dihydro Testosterone). Its action results in significant decrease in serum and tissue DHT levels in even in concentration as low as 0.2mg. Finnasteride is able to stabilize hair loss in 80% of patient with Vertex hair loss and in 70% of patients with frontal hair loss. Most of these patients are able to grow more hair or retain the ones they have. The peculiar thing about Propecia is that its effect is more pronounced in crown area than in the front. The hair that grow after the medical hair restoration treatments are better in texture and are thicker, more like the terminal hair.
The best thing about medical hair restoration treatment with the finnasteride is that it is well tolerated and has minimal side effects. Sexual dysfunction (decreased sex drive, erectile dysfunction, and decreased semen volume) are observed in about 3.8% of cases. But these side-effects subside within few months of Medical hair restoration treatments or disappear within a week’s time as soon as the treatment is stopped.
It generally requires about 6 to 12 months for the m edical hair restoration treatment to be apparent but the side effects appear earlier. So even after the medicine is stopped, there is no possibility of loosing the hair that has been gained, but the side effects are sure to disappear. Many hair restoration surgeons find Propecia (finasteride) to act as an excellent adjunct to the surgical hair restoration. There are several benefits of this kind of combination therapy. As the Medical hair restoration with Propecia brings about a hair re-growth in the crown area, it has a complementary action; it allows the surgeon to have more donor hair to be available for frontal hair transplant and design the hairline at his own will. Since finasteride has no effect in the frontal area of the scalp, it does not have any interference with the surgical hair restoration.
Combination Therapy
There are reports which say that use of finasteride and topical minoxidil combination therapy as a Medical hair restoration treatment is of more advantage in cases of mild to moderate MPHL. Further studies are in progress. Many hair restoration doctors have already started the use of combination therapy in order to obtain better hair growth.
Anti Androgen Therapy
For women with hyperandrogonism( with increased levels of androgen) who do not respond well to minoxidil, antiandrogen therapy is another option of Medical hair restoration. In UK the most commonly used anti-androgen for women is CPA (cyproterone acetate), which is used in combination with ethinyl-estradiol.
However, in United States, where CPA is not available, the aldosterone antagonist spironolactone is the alternative choice of hair restoration doctors.
Flutamide
Medical hair restoration with flutamide has shown improvement as hair loss restoration treatment in women with hirsutism. For hyperandrogenic premenopausal women, flutamide is a better medical hair restoration agent than both the CPA or finestride.
Hair loss restoration management is a structured process which depends upon many factors along with the medical hair restoration. For more details on the topic you can refer to section medical hair restoration or article on male pattern hair loss or female pattern hair loss at our site hairtransplantadvice.com.
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Current research suggests that premature ejaculation is a medical disorder with a psychological as well as a physical basis. Regarding psychological explanations, this theory often look to early male sexual experiences that conditioned rapid responsiveness. A second theory asserts that the pressure to perform under heightened anxiety may be another cause.
Scientific evidence indicates that increasing the amount of serotonin to the central nervous system through the use of selective serotonin reuptake inhibitors (SSRI's) appears to increase the latency or period of time from penetration to ejaculation. The amount of data related to serotonin levels in the brain suggests that premature ejaculation has an organic basis.
Regarding physical explanations, part of specialists agree that there are three main causes of premature ejaculation or early release during sex act: hypersensivity of penis nerves; hyperspasticity of the pelvic muscles; weakness of prostate glands.
Pharmacological treatment targets one of more from the above identified causes. The use of low dose anti-depressants including Anfronil, Clomipramine, Prozac, and Zoloft have been reported to be successful in prolonging ejaculation for many men. Levitra is now receiving increased attention from physicians as it has some good results during trials.
The Food and Drug Administration is reviewing an application for Dapoxetine, a drug similar to a family of antidepressants called selective serotonin reuptake inhibitors, which was developed by Ortho-McNeil Pharmaceutical, an affiliate of Johnson & Johnson. If approved by the FDA, Dapoxetine hydrochloride would be the first prescription treatment designed specifically to treat premature ejaculation.
To avoid the adverse drug side effects from such prescription medications many men is seeking natural remedies. There is now a new herbal formula - Climatrol - that provides natural serotonin precursors and nutrients to improve the speed of the chemical reaction in the brain. It allows more serotonin to be formed and available for use by the body while simultaneously delivering safe and effective herbal antidepressants.
